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Abstract #1027

Development of a diffusion-weighted SSFP acquisition and processing pipeline to quantify the diffusion properties of the post-mortem ALS brain at 7T

Benjamin Tendler1, Saad Jbabdi1, Sean Foxley2, Menuka Pallebage-Gamarallage3, Moises Hernandez Fernandez1, Ricarda Menke1, Thomas Nichols4, Martin Turner3, Olaf Ansorge3, and Karla Miller1

1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, University of Chicago, Chicago, IL, United States, 3Clinical Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

An acquisition and processing pipeline is outlined to quantify the diffusion properties of post-mortem brain samples from diffusion-weighted steady-state free precession (dwSSFP), as part of an ongoing project examining the impact of amyotrophic lateral sclerosis (ALS) on the human brain. Preliminary results are presented comparing the post-mortem diffusion properties of control brains and patients diagnosed with ALS over the corpus callosum. Clear trends are observed within the results, with a maximum deviation between control and ALS brains observed within callosal regions connecting the motor cortices in the two hemispheres.

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