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Abstract #1033

OGSE- versus PGSE-derived ADC measurements in patients with liver metastases show reduced hindrance to diffusion at short length scales

Mihaela Rata1, David Collins1, Maria Bali1, Thorsten Feiweier2, Julie Hughes1, Erica Scurr1, Matthew Orton1, James d`Arcy1, Martin O Leach1, and Dow-Mu Koh1

1CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden Hospital, London, United Kingdom, 2Siemens Healthcare, Erlangen, Germany

The oscillating gradient spin echo (OGSE) diffusion method probes the diffusion spectrum at defined length scales. This comparative study investigates the effect of short diffusion times on apparent diffusion coefficient (ADC) measurements using OGSE and PGSE diffusion sequences in six patients with liver metastases. Similar cohort mean ADC values were reported for all PGSE measurements, while the OGSE-derived ADC was significantly higher (paired t-test p-value=0.029). This increase in OGSE-measured ADC in liver tumours suggests that water molecules suffer less hindrance at shorter diffusion times (as already observed in brain studies) and provides additional information regarding the tissue microstructure.

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