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Abstract #1034

Prostate microstructure specificity with diffusion relaxometry

Gregory Lemberskiy1,2, Els Fieremans1, Jelle Veraart1, Andrew B. Rosenkrantz1, and Dmitry S Novikov1

1Radiology, NYU School of Medicine, New York, NY, United States, 2Sackler Institute of Graduate Biomedical Sciences, NYU School of Medicine, New York, NY, United States

We identify the contributions of prostate cellular and glandular compartments to the overall diffusion time-dependent diffusion tensor, by varying echo time and relying on their different T2 values. We test the functional form of compartment tensor eigenvalues with respect to the diffusion time against a variety of tissue models, and find the glandular tissue being best described by the short-time surface-to-volume limit, whereas the random permeable barrier model is most applicable in cellular tissue, and for tumors of various grade. Our framework allows quantification of glandular sizes, cellular fiber diameters, membrane permeability, compartment T2-values, and volume fractions.

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