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Abstract #1035

High resolution diffusion MRI maps of mice with normal and dysfunctional placentas reveal clear fetal differences

Qingjia Bao1, Eddy Solomon1, Ron Hadas2, Stefan Markovic1, Michal Neeman2, and Lucio Fydman1

1Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, 2Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel

DWI could evaluate pregnancy-related dysfunctions, yet EPI’s sensitivity to motions and air/water/fat heterogeneities prevent these studies in preclinical settings. We developed DWI methodologies based on SPatiotemporal ENcoding (SPEN) for overcoming these obstacles, delivering ADC images at ≈150µm resolutions. We demonstrate the power of these new methods to resolve placental layers (maternal, fetal, trophoblastic) and umbilical cords, as well as brain features in developing mice fetuses. Daily monitoring of pregnancies for naïve and for eNOS-/- mice also showed differences in the development of placental and fetal (e.g. brain) structures. SPEN DWI thus opens the potential for the early detection of pregnancy disorders.

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