Diffusion-weighted MR spectroscopy (DW-MRS) allows disentanglement of different pathological mechanisms of brain tissue by exploiting the specific compartmentation of metabolites in different cell types. In this study, we estimated the reproducibility of metabolite diffusion measures obtained using DW-sLASER and DW-STEAM sequences at 3T. The inter- and intra-subject variability of the apparent diffusion coefficients (ADC) of the three major metabolites, as well as the effect of the acquisition time on the variance of these measures were calculated for both sequences in two brain regions. Power calculations were performed to facilitate the choice of the optimal protocol for specific clinical needs.
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