Abstract #1064

Reproducibility and clinical feasibility of diffusion-weighted MRS using sLASER and STEAM in the human brain in vivo at 3T

Guglielmo Genovese^1,2, Lydia Yahia Cherif^1,2, Malgorzata Marjanska³, Edward J Auerbach³, Romain Valabrègue^1,2, Itamar Ronen⁴, Stéphane Lehéricy^1,2, and Francesca Branzoli^1,2

¹Brain and Spine Institute (ICM), Center for Neuroimaging Research (CENIR), Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, Paris, France, ³Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁴C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Diffusion-weighted MR spectroscopy (DW-MRS) allows disentanglement of different pathological mechanisms of brain tissue by exploiting the specific compartmentation of metabolites in different cell types. In this study, we estimated the reproducibility of metabolite diffusion measures obtained using DW-sLASER and DW-STEAM sequences at 3T. The inter- and intra-subject variability of the apparent diffusion coefficients (ADC) of the three major metabolites, as well as the effect of the acquisition time on the variance of these measures were calculated for both sequences in two brain regions. Power calculations were performed to facilitate the choice of the optimal protocol for specific clinical needs.

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