Meeting Banner
Abstract #1065

Direct signal detection of exchangeable protons of metabolites with high SNR using ultrashort-TE, short-TR 1-H MRSI without water presaturation

Wolfgang Dreher1 and Felizitas Charlotte Wermter1,2

1FB02 (Chemistry), University of Bremen, Bremen, Germany, 2Inegrative Ecophysiology, Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany

Chemical exchange saturation transfer (CEST) is a powerful technique for inverse metabolic imaging and non-invasive pH measurements, and is most efficient in the intermediate exchange regime between protons of metabolites and water. We examined the use of ultrashort-TE, short-TR MRSI for the direct signal detection of exchangeable protons of metabolites. If water is not saturated, fresh z-magnetization is transferred to the protons of metabolites, allowing a high SNR despite short TR. This approach was evaluated by simulations and measurements on creatine phantoms using solutions with different pH, demonstrating direct signal detection for exchange rates up to ~1000 s-1.

This abstract and the presentation materials are available to members only; a login is required.

Join Here