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Abstract #1082

A  Technique for Quantitatively Measuring Gas Uptake in the Lung and its Distribution to the Kidneys Using Hyperpolarized Xenon-129 MR Imaging

Hooman Hamedani1, Stephen Kadlecek1, Kai Ruppert1, Yi Xin1, Mehrdad Pourfathi1, Sarmad Siddiqui1, Faraz Amzajerdian1, Luis Loza1, Harrilla Profka1, Ryan Baron1, Tahmina Achekzai1, Shampa Chatterjee2, Maurizio Cereda3, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Physiology, University of Pennsylvania, Philadelphia, PA, United States, 3Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized 129Xe was used before to image lung function and structure. It was also shown to be a very good marker of oxygen diffusion and uptake from the lung, and a surrogate for alveolar wall thickness. Here, we demonstrated a technique for quantitatively measuring gas uptake in the lung and its distribution to the kidney and calculate the arrival time of the gas to the kidneys. Appropriate acquisition parameters will enable the same technique to be used to measure the gas’ arrival at the heart, specific vasculature, or other organs/tissue as appropriate to specific disease states.

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