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Abstract #1081

Altered Right-Heart 3D Blood Flow and Kinetic Energy in Chronic Obstructive Pulmonary Disease. The MESA COPD Study

Haben Berhane1, Ozair Rahman2, Pallavi Balte3, Kenichiro Suwa2, Stephen Dashnaw3, David A. Bluemke4, Martin R. Prince5,6, Bharath Venkatesh7, Joao Lima7, James Carr2, Antoinette S. Gomes8, Karol Watson8, Cynthia Rigsby1, R. Graham Barr3, and Michael Markl2

1Department of Medical Imaging, Lurie Children's Hospital, Chicago, IL, United States, 2Department of Radiology, Northwestern University, Chicago, IL, United States, 3Department of Medicine and Epidemiology, Columbia University, New York, NY, United States, 4Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, 5Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 6Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States, 7Division of Cardiology, John Hopkins University, Baltimore, MD, United States, 8Department of Medicine, UCLA, Los Angeles, CA, United States

Chronic Obstructive Pulmonary Disease (COPD) affects over 65 million people worldwide and is the third leading cause of death in the US. The aim of this feasibility study was to employ 4D-flow MRI for the comprehensive assessment of the effects of COPD on right-sided hemodynamics. Measures of blood kinetic energy (KE) were used to quantify hemodynamic changes in COPD patients compared to controls. Findings showed a significant increase in KE in the right atrium across increasing categories of COPD severity. Right-sided 4D flow MRI maybe a promising tool for the detection of hemodynamic disruptions in COPD and other vasoconstrictive diseases.

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