Abstract #1080

Pulmonary MRI Measurements of Ventilation Heterogeneity in Obstructive Lung Disease: Relationship to Oscillometry, Quality of Life and Disease Control

Heather M Young^1,2, Fumin Guo^1,3, Rachel L Eddy^1,2, Geoffrey N Maksym⁴, and Grace Parraga^1,2

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Graduate Program in Biomedical Engineering, Western University, London, ON, Canada, ⁴School of Biomedical Engineering, Dalhousie University, London, ON, Canada

We measured ventilation heterogeneity in 100 patients (50 asthma, 50 COPD) with hyperpolarized ³He MRI, oscillometry and quality-of-life questionnaires. We showed that MRI-measured ventilation heterogeneity is significantly related to FOT-measured small airways resistance and worsened quality-of-life for asthma and COPD patients. We also showed that MRI-measured ventilation heterogeneity is significantly increased in asthmatic patients with poor disease control. This study directly demonstrates the relationships between ³He MRI ventilation heterogeneity with small airway dysfunction and patient quality-of-life.

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