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Abstract #1079

Imaging-Based Spirometry in Chronic Obstructive Pulmonary Disease (COPD) Patients using Phase Resolved Functional Lung Imaging (PREFUL)

Andreas Voskrebenzev1,2, Filip Klimeš1,2, Marcel Gutberlet1,2, Till Kaireit1,2, Christian Schönfeld1,2, Julius Renne1,2, Heike Biller2,3, Jens Hohlfeld2,3, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, 3Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hanover, Germany

Recently, an alternative proton lung MRI Fourier Decomposition (FD) method for phase resolved functional lung imaging (PREFUL) was proposed. Using a sine model, respiratory and cardiac cycles with increased temporal resolution are obtained, enabling the assessment of dynamic parameters. Similar to flow-volume loops in spirometry, the regional ventilation can be quantified in terms of fractional ventilation (FV) loops. In this study the FV loops of six healthy volunteers and 16 chronic obstructive pulmonary disease patients are evaluated. As a metric the cross-correlation to a healthy reference is used. The results suggest potential benefits for early detection or treatment monitoring.

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