Abstract #1079

Imaging-Based Spirometry in Chronic Obstructive Pulmonary Disease (COPD) Patients using Phase Resolved Functional Lung Imaging (PREFUL)

Andreas Voskrebenzev^1,2, Filip Klimeš^1,2, Marcel Gutberlet^1,2, Till Kaireit^1,2, Christian Schönfeld^1,2, Julius Renne^1,2, Heike Biller^2,3, Jens Hohlfeld^2,3, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany, ³Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hanover, Germany

Recently, an alternative proton lung MRI Fourier Decomposition (FD) method for phase resolved functional lung imaging (PREFUL) was proposed. Using a sine model, respiratory and cardiac cycles with increased temporal resolution are obtained, enabling the assessment of dynamic parameters. Similar to flow-volume loops in spirometry, the regional ventilation can be quantified in terms of fractional ventilation (FV) loops. In this study the FV loops of six healthy volunteers and 16 chronic obstructive pulmonary disease patients are evaluated. As a metric the cross-correlation to a healthy reference is used. The results suggest potential benefits for early detection or treatment monitoring.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.