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Abstract #1078

Repeatability of ventilation and perfusion impairment assessed with matrix pencil decomposition MRI and lung function in children with cystic fibrosis

Grzegorz Bauman1,2, Sylvia Nyilas3, Orso Pusterla1,2, Enno Stranzinger4, Kathryn Ramsey3, Florian Singer3, Sophie Yammine3, Carmen Casaulta3, Philipp Latzin3, and Oliver Bieri1,2

1Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 4Departement of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, Bern, Switzerland

This study examines the repeatability of functional lung MRI using matrix pencil decomposition and lung function tests with multiple breath washout technique in children with cystic fibrosis and age-matched healthy controls. We found a good degree of the agreement between outcomes measured on two consecutive days in both groups. Furthermore, a strong correlation between functional MRI and global ventilation inhomogeneity index from multiple breath washout was observed. The results of this study highlight the potential of matrix pencil decomposition MRI for the assessment of disease progression in cystic fibrosis

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