Abstract #1078

Repeatability of ventilation and perfusion impairment assessed with matrix pencil decomposition MRI and lung function in children with cystic fibrosis

Grzegorz Bauman^1,2, Sylvia Nyilas³, Orso Pusterla^1,2, Enno Stranzinger⁴, Kathryn Ramsey³, Florian Singer³, Sophie Yammine³, Carmen Casaulta³, Philipp Latzin³, and Oliver Bieri^1,2

¹Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ⁴Departement of Diagnostic, Interventional and Paediatric Radiology, Inselspital, University Hospital Bern, Bern, Switzerland

This study examines the repeatability of functional lung MRI using matrix pencil decomposition and lung function tests with multiple breath washout technique in children with cystic fibrosis and age-matched healthy controls. We found a good degree of the agreement between outcomes measured on two consecutive days in both groups. Furthermore, a strong correlation between functional MRI and global ventilation inhomogeneity index from multiple breath washout was observed. The results of this study highlight the potential of matrix pencil decomposition MRI for the assessment of disease progression in cystic fibrosis

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