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Abstract #1084

Quantification of gas concentration and fractional ventilation using high temporal resolution MRI of pulmonary fluorinated (19F) gas washin dynamics in free breathing

Marcel Gutberlet1,2, Arnd Obert1,2, Andreas Voskrebenzev1,2, Filip Klimes1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Hannover, Germany

19F gas washin/ washout MRI allows quantification of regional lung ventilation in free breathing even in obstructed lungs. By increasing the temporal and spatial resolution of dynamic 19F gas MRI at adequate image quality lung ventilation imaging was improved. In addition to measuring regional gas washin/ washout times, gas density variations during breathing were determined, giving further information of gas dynamics and therefore lung function. Additionally, the concentration of the fluorinated gas tracer and therefore its distribution in the lung was quantified. The new approaches were tested in a healthy volunteer and a COPD patient.

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