Fluorinated gases are a cheaper alternative to hyperpolarized gas for lung ventilation imaging. However, lower resolution images are necessitated by the inherently smaller MR signal from 19F. Within this study we determine the feasibility of using C3F8 for lung ventilation imaging by comparing quantitative metrics of lung function obtained from ventilation images of 19F with those obtained from ventilation images of hyperpolarized 129Xe. A reproducibly lowered coefficient of variation distribution was observed due to lower resolution of 19F imaging. However, ventilation images acquired with 19F were of comparable SNR to those using 129Xe.
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