Abstract #1086

Dynamic 3D Isotropic Resolution Imaging of Human Lungs Using Oxygen-enhanced Radial UTE MRI

Wei Zha¹, Robert V Cadman¹, Andrew D Hahn¹, Kevin M Johnson^1,2, and Sean B Fain^1,2,3

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Oxygen-enhanced 3D radial UTE MRI (UTE OE-MRI) has the potential for dynamic imaging of oxygen wash-in and wash-out in the lungs with isotropic resolution and full chest coverage. Four normal subjects underwent DESPOT1 and ~13-min dynamic OE-MRI using 3D radial UTE MRI. Temporal variations in median percent signal enhancement (MPSE) strongly correlated (p<0.0001) in the lungs and aorta. Wash-in (0.61±0.13 min) and wash-out (0.30±0.18 min) time constants for partial pressure of oxygen (ΔPO₂) time curves are comparable to values in the literature. This study shows feasibility for dynamic imaging with whole lung coverage and isotropic spatial resolution for clinical research.

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