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Abstract #1102

Echo Time Dependence of Double Diffusion Encoding Measurements of Microscopic Diffusion Anisotropy

Grant Yang1,2 and Jennifer McNab2

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Radiology, Stanford University, Stanford, CA, United States

In this study, double diffusion encoding (DDE) MRI measurements of microscopic fractional anisotropy (μFA) are compared at two different echo times (TE). At longer TE, higher mean μFA values were measured in single fiber regions but not in crossing fiber regions. Consistent with prior work on the TE dependence of fractional anisotropy (FA) the largest differences were found in regions known to be highly myelinated such as the genu of the corpus callosum.

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