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Abstract #1113

Focused ultrasound-mediated disruption of the blood-brain barrier for targeted delivery of neurotransmitters to the rat brain

Nick Todd1, Yongzhi Zhang1, Lino Becerra2, David Borsook2, Margaret Livingstone3, and Nathan McDannold1

1Brigham and Women's Hospital, Boston, MA, United States, 2Boston Children's Hospital, Boston, MA, United States, 3Harvard Medical School, Boston, MA, United States

Here we present a novel approach to non-invasive neuromodulation that affects neuronal activity by delivering neurotransmitter chemicals to targeted areas of the brain. This is achieved by using focused ultrasound to open the blood-brain barrier in a targeted brain region such that a systemically injected neuroactive chemical will enter into the brain parenchyma only at the intended site. We demonstrate the proof of concept in a rodent model by delivering GABA to the somatosensory cortex to suppress activation from hindpaw stimulation, and by delivering glutamate to the thalamus to enhance activation downstream in the cortex from hindpaw stimulation.

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