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Abstract #1115

CBV fMRI study of the olfactory and visual processing in same mice

Fuqiang Zhao1, Xiangjun Meng1, Lynn Hyde2, Sherry Lu3, Matthew E Kennedy4, Andrea K Houghton1, Jeffrey L Evelhoch1, and Catherine D. G. Hines1

1Merck & Co., Inc., West Point, PA, United States, 2Merck & Co., Inc., Rahway, NJ, United States, 3Merck & Co., Inc., South San Francisco, CA, United States, 4Merck & Co., Inc., Boston, MA, United States

fMRI offers an excellent opportunity to study neural activations in the central nervous system. In this study, cerebral blood volume (CBV) fMRI with USPIO was used to measure simultaneous odorant and visual stimulation-induced neural activations in mice. Olfactory responses were observed in the olfactory bulb, anterior olfactory nucleus (AON), and piriform cortex (PC), while visual responses were observed in the lateral geniculate nuclei, visual cortex, and cingulate cortex. The neural phenomenon of “post-inhibition excitation rebound” was observed in the responses in AON and PC, and the fMRI phenomenon of “post-stimulus undershoot” was observed in the visual responses.

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