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Abstract #1137

Imaging Brain Clearance in the Mouse Brain: Aquaporin-4 Modulates Glymphatic Inflow

Ian F Harrison1, Ozama Ismail1, Yolanda Ohene1, Payam Nahavandi1, Jack A Wells1, and Mark F Lythgoe1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom

The ‘glymphatic’ system, which has recently been identified using MRI, is a brain-wide pathway for removal of waste solutes. This system is implicated in Alzheimer’s disease (AD), due to discovery that both amyloid-β and tau, accumulations that define AD, are cleared from the brain via this pathway. Using contrast-enhanced MRI, we demonstrate that glymphatic function is dependent upon aquaporin-4, a water channel located on astrocytic endfeet surrounding blood vessels in the brain. Herein, using a novel pharmacological approach, we show that aquaporin-4 represents a suitable drug target for manipulation of glymphatic function in the brain, and in treatment of AD.

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