In this work the influence of respiration on net CSF flow measurements was investigated.
In 12 volunteers net CSF flow was measured in the cerebral aqueduct using PC-MRI at 7T, with respiratory gating on expiration and on inspiration, and without respiratory gating. Repeated measurements were performed. Net flow over the cardiac cycle was determined.
Net CSF flow (mean±sd) was -0.64±0.32 mL/min (caudal) during expiration, +0.12±0.49 mL/min (cranial) during inspiration, and -0.31±0.18 mL/min without respiratory gating. Two outliers, with reversed (cranial) net CSF flow, were observed when no respiratory gating was performed. Repeatability was best for gating on inspiration.