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Abstract #1141

Association between Gray Matter alterations and CSF biomarkers in amnestic MCI patients

Domenico Zacà1, Giuliano Giari2, Moira Marizzoni3, Clarissa Ferrari4, Samantha Galluzzi3, Diego Albani5, Claudio Babiloni6,7, Mira Didic8, Josè Luis Molinuevo9, Flavio Mariano Nobili10, Lucilla Parnetti11, Pierre Payoux12, Paolo Maria Rossini13, Peter Schönknecht14, Andrea Soricelli15, Magda Tsolaki16, Pieter Jelle Visser17,18, Jens Wiltfang19, Regis Bordet20, Libera Cavaliere3, Jill Richardson21, Olivier Blin22, Giovanni B. Frisoni23,24, and Jorge Jovicich1

1Center for Mind/Brain Sciences-University of Trento, Trento, Italy, 2Department of Psychology and Cognitive Science-University of Trento, Trento, Italy, 3IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy, 4Service of Statistics, IRCCS Fatebenefratelli, Brescia, Italy, 5IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy, 6Department of Physiology and Pharmacology, University of Rome, Rome, Italy, 7Sapienza University of Rome, Rome, Italy, 8Aix-Marseille Universitè, Marseille, France, 9Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain, 10University of Genoa, Genoa, Italy, 11Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy, 12INSERM, Imagerie Cerebrale et Handicaps Neurologiques, Toulouse, France, 13Catholic University, Policlinico Gemelli, Rome, Italy, 14University of Leipzig, Leipzig, Germany, 15Fondazione SDN per la Ricerca e l’Alta Formazione in Diagnostica Nucleare, Naples, Italy, 16Aristotle University of Thessaloniki, Thessaloniki, Greece, 17Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands, 18VU University Medical Center, Amsterdam, Netherlands, 19University Medical Center, Goettingen, Georg-August-University, Goettingen, Germany, 20Service de Pharmacologie-Hôpital Huriez-CHRU, Lille, France, 21GSK, Neurosciences Therapeutic Area, Brentford, United Kingdom, 22Mediterranean Institute of Cognitive Neurosciences, Marseille, France, 23Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, 24Laboratory of Alzheimer’s Neuroimaging and Epidemiology - LANE, IRCCS Institute - The Saint John of God Clinical Research Centre, Brescia, Italy

In this study the association between CSF and structural imaging based early biomarker of Alzheimer Diasease (AD) was investigated in amnestic Mild Cognitive Impairment (aMCI) patients. Voxel based morphometry and partial least square correlation were used to analyze differences in local and whole brain GM profiles (covariance) between two groups of aMCI patients divided in two groups based on CSF amyloid (Aβ42) levels. Both voxel-wise and structural covariance GM differentiated Aβ positive (prodromal AD) from Aβ negative patients. These results indicate that GM measures may provide a sensitive metric for tracking AD progression.

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