Abstract #1141

Association between Gray Matter alterations and CSF biomarkers in amnestic MCI patients

Domenico Zacà¹, Giuliano Giari², Moira Marizzoni³, Clarissa Ferrari⁴, Samantha Galluzzi³, Diego Albani⁵, Claudio Babiloni^6,7, Mira Didic⁸, Josè Luis Molinuevo⁹, Flavio Mariano Nobili¹⁰, Lucilla Parnetti¹¹, Pierre Payoux¹², Paolo Maria Rossini¹³, Peter Schönknecht¹⁴, Andrea Soricelli¹⁵, Magda Tsolaki¹⁶, Pieter Jelle Visser^17,18, Jens Wiltfang¹⁹, Regis Bordet²⁰, Libera Cavaliere³, Jill Richardson²¹, Olivier Blin²², Giovanni B. Frisoni^23,24, and Jorge Jovicich¹

¹Center for Mind/Brain Sciences-University of Trento, Trento, Italy, ²Department of Psychology and Cognitive Science-University of Trento, Trento, Italy, ³IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy, ⁴Service of Statistics, IRCCS Fatebenefratelli, Brescia, Italy, ⁵IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy, ⁶Department of Physiology and Pharmacology, University of Rome, Rome, Italy, ⁷Sapienza University of Rome, Rome, Italy, ⁸Aix-Marseille Universitè, Marseille, France, ⁹Alzheimer’s Disease Unit and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain, ¹⁰University of Genoa, Genoa, Italy, ¹¹Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy, ¹²INSERM, Imagerie Cerebrale et Handicaps Neurologiques, Toulouse, France, ¹³Catholic University, Policlinico Gemelli, Rome, Italy, ¹⁴University of Leipzig, Leipzig, Germany, ¹⁵Fondazione SDN per la Ricerca e l’Alta Formazione in Diagnostica Nucleare, Naples, Italy, ¹⁶Aristotle University of Thessaloniki, Thessaloniki, Greece, ¹⁷Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands, ¹⁸VU University Medical Center, Amsterdam, Netherlands, ¹⁹University Medical Center, Goettingen, Georg-August-University, Goettingen, Germany, ²⁰Service de Pharmacologie-Hôpital Huriez-CHRU, Lille, France, ²¹GSK, Neurosciences Therapeutic Area, Brentford, United Kingdom, ²²Mediterranean Institute of Cognitive Neurosciences, Marseille, France, ²³Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, ²⁴Laboratory of Alzheimer’s Neuroimaging and Epidemiology - LANE, IRCCS Institute - The Saint John of God Clinical Research Centre, Brescia, Italy

In this study the association between CSF and structural imaging based early biomarker of Alzheimer Diasease (AD) was investigated in amnestic Mild Cognitive Impairment (aMCI) patients. Voxel based morphometry and partial least square correlation were used to analyze differences in local and whole brain GM profiles (covariance) between two groups of aMCI patients divided in two groups based on CSF amyloid (Aβ42) levels. Both voxel-wise and structural covariance GM differentiated Aβ positive (prodromal AD) from Aβ negative patients. These results indicate that GM measures may provide a sensitive metric for tracking AD progression.

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