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Abstract #1143

Quantitative Modeling of Glymphatic Pathways of the Brain Using MRI

Esmaeil Davoodi-bojd1, Guangliang Ding1, Li Zhang1, Qingjiang Li1, Lian Li1, Michael Chopp1,2,3, and Quan Jiang1,2,3

1Neurology, henry ford health system, detroit, MI, United States, 2Neurology, Wayne State University, detroit, MI, United States, 3Physics, Oakland University, Rochester, MI, United States

The dynamic exchange of CSF with ISF is identified as the glymphatic system. The impairment of the glymphatic clearance is involved in the development of neurodegenerative conditions. Despite many recent studies that investigated the glymphatic system, few studies have tried to use a mathematical model to describe this system, quantitatively. In this study, we aim to model the glymphatic system from the kinetics of GD-DTPA tracer in order to 1) map the glymphatic system pathways, 2) derive kinetic parameters of the glymphatic system, and 3) provide quantitative maps of the structure and function of this system.

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