Meeting Banner
Abstract #1144

Phase-contrast MRI for estimating global cerebral blood flow of mice at 11.7T: optimization and age-dependence

Zhiliang Wei1,2, Lin Chen1,2,3, Zixuan Lin4, Jiadi Xu1,2, Peter van Zijl1,2, and Hanzhang Lu1,2,4

1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, 3Department of Electronic Science, Xiamen University, Xiamen, Fujian, China, 4Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States

Cerebral blood flow (CBF) is a crucial physiological parameter reflective of brain functioning and metabolism. In this study, our goal was to systematically optimize a phase-contrast (PC) quantitative flow technique for CBF assessment in mice. We also demonstrated the sensitivity of this technique to longitudinal CBF changes in aging. This optimized PC protocol may serve as a helpful non-invasive tool for CBF measurement in preclinical studies of brain physiology and pathophysiology with mouse disease models.

This abstract and the presentation materials are available to members only; a login is required.

Join Here