Abstract #1144

Phase-contrast MRI for estimating global cerebral blood flow of mice at 11.7T: optimization and age-dependence

Zhiliang Wei^1,2, Lin Chen^1,2,3, Zixuan Lin⁴, Jiadi Xu^1,2, Peter van Zijl^1,2, and Hanzhang Lu^1,2,4

¹Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Xiamen, Fujian, China, ⁴Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States

Cerebral blood flow (CBF) is a crucial physiological parameter reflective of brain functioning and metabolism. In this study, our goal was to systematically optimize a phase-contrast (PC) quantitative flow technique for CBF assessment in mice. We also demonstrated the sensitivity of this technique to longitudinal CBF changes in aging. This optimized PC protocol may serve as a helpful non-invasive tool for CBF measurement in preclinical studies of brain physiology and pathophysiology with mouse disease models.

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