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Abstract #1145

Impact of the glymphatic system on the kinetic and distribution of gadodiamide in the rat brain: Observation by dynamic MRI and effect of circadian rhythm on tissue gadolinium concentrations.

Toshiaki Taoka1, Gregor Jost2, Shinji Naganawa1, and Hubertus Pietsch2

1Nagoya University, Nagoya, Japan, 2MR&CT Contrast Media Research, Bayer AG, Berlin, Germany

We tried to elucidate the role of the glymphatic system on the distribution and kinetics of a linear gadolinium based contrast agent in the rat brain. Dynamic MRI signal changes of the brain and the cerebrospinal fluid (CSF) indicated that intravenously administrated gadodiamide enter from blood into the CSF, indicating the involvement of the glymphatic system. The long term presence of gadolinium in the brain after repeated administration of gadodiamide quantified by ICP-MS indicates the involvement of the glymphatic system on the clearance of gadolinium from brain tissue in terms of the influence of circadian rhythm and anesthesia during administration.

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