Meeting Banner
Abstract #1149

Carnitine supplementation improves skeletal muscle acetylcarnitine formation and metabolic flexibility

Yvonne MH Bruls1, Marlies de Ligt2, Esther Phielix2, Bas Havekes3, Joachim E Wildberger1, Matthijs K Hesselink2, Patrick Schrauwen2, Lucas Lindeboom1,2, and Vera B Schrauwen-Hinderling1,2

1Department of Radiology & Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, 2Department of Human Biology & Human Movement Sciences, Maastricht University Medical Center +, Maastricht, Netherlands, 3Department of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center +, Maastricht, Netherlands

The formation of acetylcarnitine may serve as a mitochondrial rescue mechanism to prevent the development of metabolic inflexibility and type 2 diabetes. We here used a novel magnetic resonance spectroscopy protocol, using long echo times, to determine acetylcarnitine concentrations in skeletal muscle in vivo. Carnitine supplementation enhanced the increase in acetylcarnitine concentration in resting muscle over the day as well as the capacity to form acetylcarnitine with exercise. Furthermore, carnitine supplementation completely restored metabolic flexibility suggesting that carnitine supplementation may be an interesting aid in improving disturbed metabolism in subjects prone to develop type 2 diabetes mellitus.

This abstract and the presentation materials are available to members only; a login is required.

Join Here