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Abstract #1150

Why does a transient NAD+ infusion lead to a sustained increase in brain ATP levels? - A dynamic 31P MRS-MT imaging investigation at ultrahigh field

Xiao-Hong Zhu1, Ming Lu1, Yi Zhang1, and wei Chen1

1Center of Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, United States

It has been observed recently that transient intraperitoneal infusion of oxidized nicotinamide adenine dinucleotide (NAD+) can increase intracellular ATP levels in healthy rat brain over time. Intrigued by this fascinating phenomenon, we investigated the dynamic changes of major phosphorous metabolites and the kinetics and metabolic rates of the ATP synthesis reactions in rat brain before and after introducing exogenous NAD+ using combined in vivo 31P MR spectroscopy (MRS) imaging with magnetization transfer (MT) technique at 16.4 Tesla magnet. The results of this comprehensive study provide important information for elucidating the cerebral energetic mechanism and regulation underlying this phenomenon.

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