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Abstract #1163

Radiomics of DCE-MRI to selectively down-stage the risk of breast cancers with a high-risk 70-gene signature

Hui Shan Chan1, Tycho Bismeijer2, Bas van der Velden1, Jelle Wesseling2, Esther Lips2, Claudette Loo2, Lodewyk Wessels2, and Kenneth Gilhuijs1

1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands, 2Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands

The 70-gene signature (70GS) is a prognostic marker for patient survival that is used to guide treatment decisions. For a dataset of early-stage breast cancer patients, the 70GS were established retrospectively. We investigated the potential of DCE-MRI to stratify patient survival within the high-risk 70GS group. Eigentumor analysis and 3D lesion texture features from washin and post-contrast images were compared in survival analysis and hazard ratios were computed. Results show that the investigated features are able to significantly stratify survival, and suggest that radiomics of DCE-MRI may have complementary value to the 70-gene signature to reduce overtreatment.

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