This study investigates real-time head motion correction using markerless tracking of the subject's face to mitigate the major problems caused by patient movement in clinical and research MRI. The effects of motion include repeat scanning, impaired clinical diagnosis, need for sedation or anesthesia, and biased research results. Markerless tracking and correction is appealing because it could offer minimal disruption to the MRI workflow, sequence independence, and high-frequency motion estimation. Real-time correction substantially improved T2-SPACE and MPRAGE image quality in scans with intentional motion, compared to uncorrected scans. Cortical surface reconstructions, brain structure volumes, and cortical thickness estimated from the motion-corrected MPRAGE scan showed good correspondence with the gold standard scans without intentional movement. Markerless real-time correction is a promising approach to reduce the effects of motion in neuro MRI.