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Abstract #1166

Radiomics subtyping improves 5-year disease free survival prediction beyond key clinical and radiological characteristics in patients with locally advanced rectal cancer (LARC)

Ke Nie1, Peng Hu2, Fei Peng3, Tingyu Mao4, Xiao Wang1, Ning Yue1, and Jihong Sun2

1Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, United States, 2Department of Radiological Sciences, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, 3Institute of Translational Medicine´╝îZhejiang University, Hangzhou, China, 4Department of Electrical Engineering, Columbia University, New York, NY, United States

In this study, we have identified an 11-feature set from a large panel of radiomics signature (5248 features from pre-operative T1w, T2w, DCE and DWI images) that allows prediction of 5-year disease free survival of locally advanced rectal cancer patients underwent surgical resection. The selected radiomics signature demonstrates improved performance compared with that of established clinical and radiological risk models. The results were tested and validated on a consecutive 165-patient cohort with an average of 54┬▒20 months follow-ups.

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