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Abstract #1165

Proton MRS-Detected Creatine Metabolic Profiles in Human Breast Cancer Cells Correlate with the Prognostic Indicator Ubiquitous Mitochondrial Creatine Kinase (CKMT1)

Vinay Ayyappan1, Menglin Cheng1, Ruoqing Cai1, Caitlin Tressler1, Kanchan Sonkar1, Michael T. McMahon2, and Kristine Glunde1

1Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Ubiquitous mitochondrial creatine kinase (CKMT1) is an important mitochondrial membrane component responsible for the reversible conversion of creatine (Cr) to phosphocreatine (PCr). This study shows that in five breast cell lines of varying aggressiveness, 1H MRS-detected PCr levels correlated with CKMT1 mRNA expression. CKMT1 expression was significantly downregulated in triple-negative breast cancer cells compared to estrogen receptor (ER)/ progesterone receptor (PR)-positive cells, and nonmalignant cells. CKMT1 is a prognostic indicator in several cancers; thus, PCr holds promise as potential marker for improved cancer diagnosis, patient stratification, and theranostic treatment monitoring.

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