Abstract #1179

Ex vivo MRI evaluation of vulvar cancer in fresh wide local excision specimens for cancer localization and prediction of the surgical tumour free margins.

Jan Heidkamp¹, Petra Zusterzeel², Andor Veltien¹, Arie Maat³, Ilse van Engen-van Grunsven³, Maroeska Rovers⁴, and Jurgen Fütterer¹

¹Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Obstetrics and Gynaecology, Radboud university medical center, Nijmegen, Netherlands, ³Pathology, Radboud university medical center, Nijmegen, Netherlands, ⁴Operating Rooms, Radboud university medical center, Nijmegen, Netherlands

Currently, perioperative information on the surgical margin status of wide local excision specimens containing vulvar cancer is only based on the surgeon’s estimation. In this study we performed both a non-blinded and a blinded annotation of vulvar cancer location and surgical tumour free margins in the ex vivo MRI obtained from fresh wide local excision specimens. Annotated whole-mount section histopathology slides obtained from totally included specimens were adhered as gold standard. There was high correlation and agreement between ex vivo MRI, and high NPV and PPV were obtained for vulvar cancer localization and identification of margins <8 mm.

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