Texture analysis of multiparametric MRI (mpMRI) consisting of diffusion-weighted MRI (DWI) and T2-weighted (T2W) texture features could be a promising quantitative approach in assessing tumor heterogeneity. We retrospectively studied forty patients who had paired mpMRI examinations before and at week-4 of chemoradiotherapy (CRT). Based on the changes in stable mpMRI features, we observed that initially more anatomically and functionally homogenous tumors had better response to treatment and that tumors became more functionally heterogenous after treatment.
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