Abstract #1184

4D flow MRI in renal transplant: preliminary results.

Octavia Bane^1,2, Sara Lewis^1,2, Stefanie Hectors^1,2, Sonja Gordic^2,3, Paul Kennedy^1,2, Mathilde Wagner^2,4, Michael Markl^5,6, Rafael Khaim⁷, Veronica Delaney⁷, Fadi El Salem⁸, Madhav Menon⁷, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ²Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ³University Hospital Zurich, Zurich, Switzerland, ⁴Groupe Hospitalier Pitie-Salpetriere, Paris, France, ⁵Feinberg School of Medicine, Radiology, Northwestern University, Chicago, IL, United States, ⁶McCormick School of Engineering, Biomedical Engineering, Northwestern University, Chicago, IL, United States, ⁷Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ⁸Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

In this preliminary study, we sought to determine the test-retest repeatability of flow quantification in renal allograft vessels using a 4D flow phase-contrast (PC) MRI sequence, and to correlate flow parameters with renal function. We observed significantly decreased renal arterial flow in allografts with chronic dysfunction, as well as positive correlation between flow and velocities in renal transplant vessels and renal function. We conclude that 4D flow imaging is sensitive to the vascular changes that accompany renal transplant dysfunction, to be confirmed in a larger study.

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