Abstract #1185

Free-breathing R2* Mapping in the Entire Placenta During Early Gestation Using 3D Stack-of-Radial MRI at 3 T: Investigation of Spatial and Temporal Variation

Tess Armstrong^1,2, Dapeng Liu¹, Thomas Martin^1,2, Cass Wong¹, Irish Del Rosario³, Sherin U. Devaskar⁴, Carla Janzen⁵, Teresa Chanlaw⁴, Rinat Masamed¹, Kyunghyun Sung^1,2, and Holden H. Wu^1,2

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Epidemiology, University of California Los Angeles, Los Angeles, CA, United States, ⁴Pediatrics, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, United States, ⁵Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, United States

Current methods for detecting ischemic placental disease are either invasive or have low sensitivity. MRI can be used to non-invasively characterize tissue hypoxia with R₂* mapping. However, conventional Cartesian MRI methods are sensitive to motion artifacts due to maternal and fetal motion. In this study, a non-Cartesian free-breathing 3D stack-of-radial MRI technique (FB radial) for R₂* mapping in the placenta during early gestation was investigated at 3T. In 20 subjects, placental R₂* range, accuracy, repeatability, spatial variation, and temporal variation were analyzed. Results demonstrate that FB radial is an accurate and repeatable technique for R₂* mapping in the entire placenta.

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