Placental dysfunction is widely accepted as a major cause of common adverse pregnancy outcomes. However, current clinically available tools are limited in their ability to assess placental function. Here, we have incorporated quantitative MRI methods to estimate placental metabolic rate of O2 (PMRO2), which may contribute to the understanding of placental dysfunction. Presented results demonstrate the feasibility of estimating PMRO2 in vivo. Further, these data suggest, in a limited number of participants, that PRMO2 may in fact contribute to the understanding of pregnancy complications.