Abstract #1186

Placental Metabolic Rate of Oxygen

Ana E Rodríguez-Soto¹, Michael C Langham¹, Eileen E Hwuang², Walter R Witschey¹, Nadav E Schwartz³, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Pennsylvania, Philadelphia, PA, United States

Placental dysfunction is widely accepted as a major cause of common adverse pregnancy outcomes. However, current clinically available tools are limited in their ability to assess placental function. Here, we have incorporated quantitative MRI methods to estimate placental metabolic rate of O₂ (PMRO₂), which may contribute to the understanding of placental dysfunction. Presented results demonstrate the feasibility of estimating PMRO₂ in vivo. Further, these data suggest, in a limited number of participants, that PRMO₂ may in fact contribute to the understanding of pregnancy complications.

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