Abstract #1187

Feasibility of Blood-Brain Barrier Opening in Patients with Alzheimer’s Disease by MR-Guided Focused Ultrasound

Yuexi Huang¹, Nir Lipsman^2,3, Ying Meng^2,3, Allison J. Bethune³, Benjamin Lam^3,4, Mario Masellis^3,4, Nathan Herrmann^3,5, Chinthaka Heyn^1,6, Isabelle Aubert^1,3, Alexandre Boutet⁶, Gwenn S. Smith⁷, Sandra E. Black^3,4, and Kullervo Hynynen^1,8

¹Sunnybrook Research Institute, Toronto, ON, Canada, ²Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Department of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, ⁸Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

In a phase I clinical trial, the feasibility and safety of focal blood-brain barrier (BBB) opening in patients with Alzheimer’s disease using the ExAblate focused ultrasound system was evaluated. Six patients were treated in the white matter of the prefrontal cortex. It was demonstrated that BBB opening can be achieved without any red-blood-cell extravasation.

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