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Abstract #1187

Feasibility of Blood-Brain Barrier Opening in Patients with Alzheimer’s Disease by MR-Guided Focused Ultrasound

Yuexi Huang1, Nir Lipsman2,3, Ying Meng2,3, Allison J. Bethune3, Benjamin Lam3,4, Mario Masellis3,4, Nathan Herrmann3,5, Chinthaka Heyn1,6, Isabelle Aubert1,3, Alexandre Boutet6, Gwenn S. Smith7, Sandra E. Black3,4, and Kullervo Hynynen1,8

1Sunnybrook Research Institute, Toronto, ON, Canada, 2Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, 4Division of Neurology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 5Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 7Department of Psychiatry and Behavioral Sciences and Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, 8Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

In a phase I clinical trial, the feasibility and safety of focal blood-brain barrier (BBB) opening in patients with Alzheimer’s disease using the ExAblate focused ultrasound system was evaluated. Six patients were treated in the white matter of the prefrontal cortex. It was demonstrated that BBB opening can be achieved without any red-blood-cell extravasation.

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