Abstract #1188

Noninvasive neuromodulation induced by focused ultrasound combined with fMRI in the non-human primate brain

Tingting He#¹, Chih-Hung Tsai#², Ssu-Ju Li³, Xianfeng Feng¹, Kaiyue Wang¹, Chao-Ting Wang^1,2, Xiao Yu¹, Wei Xiong¹, You-Yin Chen³, Hao-Li Liu*^1,2, and Hsin-Yi Lai*¹

¹Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou City, China, ²School of Medicine, Department of Electrical Engineering, Chang Gung University, Taoyuan County, Taiwan, ³Department of Biomedical Engineering, National Yang-Ming University, Taipei City, Taiwan

Currently, the field of neuromodulation using focused ultrasound is growing due to its potential clinical applications. Using the lab-designed MRI-compatible FUS transducer and 7T research MRI system with the customer-made transmit/receive surface coil, the current study demonstrated that focused ultrasound (FUS) can induce BOLD responses in visual cortex in non-human primate. The effect of FUS could sostenuto influence the neuron activity in the visual cortex to enhance BOLD responses evoked by visual stimulus. FUS combined with fMRI has potential to explore the mechanism of neuromodulation in NHP induced by focused ultrasound.

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