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Abstract #1188

Noninvasive neuromodulation induced by focused ultrasound combined with fMRI in the non-human primate brain

Tingting He#1, Chih-Hung Tsai#2, Ssu-Ju Li3, Xianfeng Feng1, Kaiyue Wang1, Chao-Ting Wang1,2, Xiao Yu1, Wei Xiong1, You-Yin Chen3, Hao-Li Liu*1,2, and Hsin-Yi Lai*1

1Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou City, China, 2School of Medicine, Department of Electrical Engineering, Chang Gung University, Taoyuan County, Taiwan, 3Department of Biomedical Engineering, National Yang-Ming University, Taipei City, Taiwan

Currently, the field of neuromodulation using focused ultrasound is growing due to its potential clinical applications. Using the lab-designed MRI-compatible FUS transducer and 7T research MRI system with the customer-made transmit/receive surface coil, the current study demonstrated that focused ultrasound (FUS) can induce BOLD responses in visual cortex in non-human primate. The effect of FUS could sostenuto influence the neuron activity in the visual cortex to enhance BOLD responses evoked by visual stimulus. FUS combined with fMRI has potential to explore the mechanism of neuromodulation in NHP induced by focused ultrasound.

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