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Abstract #1189

In vivo MR-ARFI for transcranial focused ultrasound in large animals

Pooja Gaur1, Ningrui Li2, Rachelle Bitton1, and Kim Butts Pauly1

1Radiology, Stanford University, Stanford, CA, United States, 2Electrical Engineering, Stanford University, Stanford, CA, United States

Focused ultrasound through the skull is desirable for noninvasive brain therapies such as neuromodulation. However, the skull distorts the ultrasound beam and absorbs varying amounts of energy depending on bone thickness and composition. In light of these challenges, we investigate magnetic resonance acoustic radiation force imaging (MR-ARFI) focal spot imaging of subcortical brain tissue in a large animal, and simulations and measurements of acoustic pressure transmitted through the skull. Results show in vivo MR-ARFI focal spot imaging through the skull for the first time, and provide practical information on focal spot targeting through skulls of varying shape, thickness, and composition.

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