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Abstract #1194

Intra-vascular, MRI-Guided, perivascular ultrasound ablation with thermometric monitoring of therapy delivery

Xiaoyang Liu1,2, Nicholas Ellens2,3, Emery Williams4, Clif Burdette4, Parag Karmarkar2, and Paul Bottomley1,2

1Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, 2Russell H. Morgan Dept. of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Acertara Acoustic Laboratories, Longmont, CO, United States, 4Acoustic MedSystems, Inc, Champaign, IL, United States

Vessel invasion from a tumor is a major challenge for both surgical resection and extracorporeal HIFU ablation. Conceivably, an intravascular ultrasound ablation catheter combined with an intravascular high-resolution MRI coil could precisely target and monitor of peri-vascular therapy delivery that preserves the vessel wall via MRI thermometry. We present results from an intra-vascular 3T ultrasound ablation/MRI antenna probe that document MRI thermometry-based thermal dosage and lesion formation in porcine liver and chicken specimens with vessel wall preservation. A simple motion-correction method that employs the antenna’s intrinsic sensitivity profile as a navigator for thermometry is tested in vivo.

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