Abstract #1199

A multi-center study on fast full-brain quantitative multi-parameter mapping of R1, MT, and R2*: scan-rescan repeatability and inter-site reproducibility

Maryam Seif^1,2, Tobias Leutritz², Rebecca S Samson³, Armin Curt¹, Claudia Angela Gandini Wheeler-kingshott^3,4,5, Patrick Freund^1,2,6, and Nikolaus Weiskopf²

¹Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, ²Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany, ³Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

We present a multi-center, multi-vendor study evaluating repeatability and reproducibility of quantitative MRI data acquired using high resolution (1 mm³) multi-parameter mapping which provides quantitative R1, MT and R2* maps of the whole brain within less than 18 min. The protocol was implemented at four clinical sites with different Siemens and Philips 3T MRI scanners. Scan-rescan measurements of the same five healthy volunteers at all sites showed good intra-site reproducibility in all parameter maps. However, the inter-site comparisons showed higher reproducibility within a single vendor than across vendors.

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