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Abstract #1199

A multi-center study on fast full-brain quantitative multi-parameter mapping of R1, MT, and R2*: scan-rescan repeatability and inter-site reproducibility

Maryam Seif1,2, Tobias Leutritz2, Rebecca S Samson3, Armin Curt1, Claudia Angela Gandini Wheeler-kingshott3,4,5, Patrick Freund1,2,6, and Nikolaus Weiskopf2

1Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 2Max Planck Institute for Human Cognitive and Brain Science, Leipzig, Germany, 3Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 5Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy, 6Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

We present a multi-center, multi-vendor study evaluating repeatability and reproducibility of quantitative MRI data acquired using high resolution (1 mm³) multi-parameter mapping which provides quantitative R1, MT and R2* maps of the whole brain within less than 18 min. The protocol was implemented at four clinical sites with different Siemens and Philips 3T MRI scanners. Scan-rescan measurements of the same five healthy volunteers at all sites showed good intra-site reproducibility in all parameter maps. However, the inter-site comparisons showed higher reproducibility within a single vendor than across vendors.

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