In this work, we present a new method for motion-insensitive 3D multi-shot diffusion imaging, by using 3D Diffusion Imaging with SPiral Encoded Navigators from Stimulated Echoes (3D DISPENSE). The 3D spiral navigator is acquired with a single readout and generated between diffusion preparation and image acquisition from the twin-pathway of the stimulated echo TSE imaging signal pathway. Therefore, the proposed 3D navigator technique does not compromise diffusion weighting or TSE readout efficiency. We demonstrated the feasibility of this method in phantoms, as well as by in vivo 3D high resolution artifact-free diffusion tensor imaging with nearly full brain coverage.
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