DIADEM (Distortion-free Imaging: A Double Encoding Method) is a hybrid, multi-shot approach using a spin-warp and echo-planar phase-encoding strategy. It is inspired by the point-spread-function mapping method to enable distortion-free high-resolution diffusion imaging, which has a great potential for clinical practice. However, its prolonged scan time poses an obstacle for its adoption. We demonstrate that DIADEM achieves high-resolution (1.4 mm3 isotropic or 0.86 mm2 in-plane), distortion-free, and whole-brain, diffusion tensor images under 9 minutes scan time with: i) sequence optimization and ii) the high-performance gradients (80 mT/m, 700 T/m/s) on a compact 3T MRI.
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