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Abstract #1204

Fast Distortion-Free Diffusion Imaging using “tilted-CAIPI” PSF-EPI

Zijing Dong1, Fuyixue Wang2,3, Timothy G. Reese2, Mary Kate Manhard2, Berkin Bilgic2, Lawrence L. Wald2,3, Hua Guo1, and Kawin Setsompop2,3

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Single-shot EPI is widely used for diffusion imaging, but suffers from susceptibility-induced distortion and T2* blurring, which limit its resolution and ability to detect detailed structures. PSF-encoded EPI with an added 2D-navigator has recently been developed to allow distortion- and blurring- free diffusion imaging. However, the extremely long acquisition of PSF-EPI makes it impractical for high angular resolution diffusion imaging. In this work, PSF-EPI is accelerated by >20x using a novel “tilted-CAIPI” approach, along with self-navigation strategy. This has enabled distortion- and blurring-free diffusion imaging at 1.2mm isotropic to be acquired with 48 diffusion directions in 21-minutes for whole-brain.

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