Meeting Banner
Abstract #1213

MouseStream: A Software Suite for Mapping and Analyzing Mouse Cortical Functional Architecture In Vivo Using Magnetic Resonance Microscopy

Jia Guo1, Xinyang Feng1, Hannah Sigmon2, Frank Provenzano2, and Scott A. Small3

1Department of Biomedical Engineering, Columbia University, New York, NY, United States, 2Departments of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, United States, 3Departments of Neurology, Radiology or Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, United States

The functional architecture of the cortex has never been mapped in vivo with the fidelity necessary to distinguish “functional unit”. Mapping the functional architecture of the cortex, reflecting the observed regional and layer differences in synaptic density and its correlate energy metabolism, has been very challenging. Here we set out to address this issue by in vivo high-resolution cerebral blood volume (CBV) mapping of the mouse cortex. Tailored software, MouseStream, was developed to reconstruct the cortical CBV data through the normalized curved cortical coordinate (NCCC). NCCC allows projection of functional architectures mapped using CBV onto the cortical surface across the whole cortex and from different cortical depths.

This abstract and the presentation materials are available to members only; a login is required.

Join Here