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Abstract #1214

Longitudinal alterations of resting-state functional connectivity in Alzheimer’s disease in a tauopathy mouse model

Laetitia Degiorgis1, Meltem Karatas1,2,3,4, Marion Sourty1, Thomas Bienert3, Marco Reisert3, Chantal Mathis5, Anne-Laurence Boutillier5, Frédéric Blanc1,6, Jean-Paul Armspach1, and Laura-Adela Harsan1,3,7

1ICube, University of Strasbourg, CNRS, Strasbourg, France, 2Faculty of Biology, University of Freiburg, Strasbourg, France, 3Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg im Breisgau, Germany, 4INCI University of Strasbourg, Strasbourg, France, 5LNCA, University of Strasbourg, Strasbourg, France, 6Centres Mémoire de Ressources et de Recherche, CHU de Strasbourg, Services Neurologiques et Gériatriques, Strasbourg, France, 7Département de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

Alzheimer’s disease is the most widespread cause of dementia and constitutes one of the biggest challenges for society. Among dominant mechanisms of the disease is the abnormal accumulation of the protein tau leading to tauopathy. In this study we explored in vivo the longitudinal evolution of the brain functional connectome, in the Thy-Tau22 mouse, a model of tauopathy. We used resting-state functional MRI in correlation with behavioral analysis to show the remodeling functional circuitry over-time including default mode network and memory networks in transgenic mice.

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