Abstract #1224

In-vivo correlations between hemodynamics and wall inflammation in patients with intracranial aneurysms: comparing 4D Flow MRI and vessel wall enhancement.

Myriam EDJLALI¹, Dahan Kim², Leonardo Rivera-Rivera², Pauline Roca¹, Catherine Oppenheim¹, Olivier Naggara¹, Patrick Turski³, Oliver Wieben², and Kevin M Johnson²

¹Neuro-Radiology, Centre Hospitalier Sainte-Anne, Paris, France, ²department of medical physics, University of Wisconsin, Madison, WI, United States, ³department of Radiology, University of Wisconsin, Madison, WI, United States

Recent studies point out hemodynamics and wall inflammation as individual risk factors for aneurysm evolution. We investigated on 28 aneurysms in-vivo correlations between hemodynamics and wall inflammation by comparing 4D Flow parameters and quantitative aneurysm wall enhancement. Viscous energy loss and kinetic energy were correlated to maximum values of enhancement with high correlation coefficients (p<0.0001; correlation coefficient 0.79 and p<0.0001; correlation coefficient 0.85, respectively). By showing that flow instability and spatial flow complexity are highly correlated with aneurysm wall enhancement, this study highlights the existence of a link between inflammation process depicted through vessel wall enhancement and hemodynamic patterns.

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