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Abstract #1235

Supratentorial reorganization after treatment for childhood infratentorial tumors from a graph theoretical perspective

Charlotte Sleurs1,2, Dafnis Batalle3, Jurgen Lemiere1, Daan Christiaens3, Jacques-Donald Tournier3, Stefan Sunaert2, Anne Uyttebroeck1, Sandra Jacobs1, Serena Counsell3, and Sabine Deprez2

1Pediatric Hemato-Oncology, UZ Leuven, Leuven, Belgium, 2Radiology, UZ Leuven, Leuven, Belgium, 3Perinatal Imaging & Health, King's College London, London, United Kingdom

In this study, structural brain topology was investigated in young adults who were treated for infratentorial tumors during childhood, using graph theory metrics based on whole-brain tractography. Comparisons with healthy controls yielded significant differences in global efficiency measures, independently from network density threshold. This cost-corrected measure was significantly related with IQ scores. By contrast, local efficiency and average nodal strength appeared different for core networks only. This finding suggests that connectivity of highly connected supratentorial hubs are predominantly affected following treatment for infratentorial tumours.

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