Meeting Banner
Abstract #1236

Effect of Vascular Input Function Selection on Quantitative Dynamic Contrast-Enhanced MRI for Differentiating Pseudo-progression from True Progression in Glioblastomas

Kevin Yuqi Wang1, Melissa Chen2, and Ho-Ling Liu3

1Radiology, Baylor College of Medicine, Houston, TX, United States, 2Diagnostic Radiology, MD Anderson, Houston, TX, United States, 3Imaging Physics, MD Anderson, Houston, TX, United States

Vascular input function (VIF) is a major source of error in the pharmacokinetic modeling of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) data. We investigated the influence of VIF variability on forward volumetric transfer constant, Ktrans, one of the kinetic parameters of DCE MRI. The diagnostic power of DCE MRI to discriminate between pseudo-progression and true progression of glioblastoma following chemoradiation therapy was determined by deriving Ktrans from five different VIF sources (population-based, middle cerebral artery, superior sagittal sinus—the latter two calculated by applying either an assumed or a measured T1) and using receiver operating curve analysis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here