Abstract #1264

Multiphase Hepatocyte-Specific Contrast Enhanced MRI of Liver in a Non-Human Primate Model of Ebola

Ji Hyun Lee¹, David Thomasson¹, Jeffrey Solomon², Joseph Laux¹, Katie R. Hagen¹, Robin Gross¹, Peter B. Jahrling^1,3, Irwin M. Feuerstein¹, and Reed F. Johnson³

¹Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institute of Health, Frederick, MD, United States, ²Clinical Research Directorate/Clinical Monitoring Research Program, NCI Campus at Frederick, Leidos Biomedical Research, Inc., Frederick, MD, United States, ³Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institute of Health, Frederick, MD, United States

The purpose of this experiment was to assess the impact of Ebola virus infection on liver function during the acute phase of Ebola virus disease (EVD) in the rhesus macaque model in vivo imaging in a Biosafety level-4 facility. Multiphase liver-specific contrast, Eovist, enhanced MRI technique could detect the EVD liver failure. We observed a decreasing trend of Eovist uptake in the liver and biliary execution, and an increasing trend of liver volume with disease progression. Our findings highlight the spatiotemporal differences in Eovist uptake in a non-human primate model of Ebola.

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