Abstract #1270

Vagus Nerve Stimulation Promotes Gastric Emptying in Rat Measured by Magnetic Resonance Imaging

Kun-Han Lu¹, Jiayue Cao², Steven Oleson², Matthew Ward^2,3, Terry Powley⁴, and Zhongming Liu^1,2

¹Electrical and Computer Engineering, Purdue University, West lafayette, IN, United States, ²Biomedical Engineering, Purdue University, West lafayette, IN, United States, ³Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Psychological Sciences, Purdue University, West lafayette, IN, United States

We developed in vivo contrast-enhanced MRI and an image processing pipeline to image and assess the therapeutic effect of cervical vagus nerve stimulation (VNS) on gastric emptying and motility in rat. We found that: (1) VNS significantly promoted the rate of gastric emptying. (2) VNS significantly increased the degree to which the pyloric ring opened, and this outcome was correlated to the rate of gastric emptying. (3) The VNS parameters used in this study did not alter antral motility significantly. The proposed method allows non-invasive and repeated preclinical imaging of gastric physiology and diseases given electroceutical treatments.

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