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Abstract #1269

Non-invasive T1 mapping of the vitreous humour can detect central retinal vein occlusion and may discriminate between other forms of retinal ischaemia

Nicholas G Dowell1, Andrew R H Simpson2, Samira N Bouyagoub1, and Edward H Hughes2

1Neuroscience, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Sussex Eye Hospital, Brighton and Sussex University Hospital, Brighton, United Kingdom

In this work we demonstrate that careful T1 mapping of the vitreous humour can identify disease in the retina. We studied a cohort of patients with central vein retinal occlusion (a type of retinal ischaemia) and show that significant decreases in T1 of the vitreous humour are observed compared to healthy control eyes. We speculate that the decreases may be the result of increased pO2 that could arise when the oxygen demand of the retina is reduced as a consequence of damage. We show preliminary data from patients with proliferative diabetic retinopathy and ocular ischaemic syndrome that suggest that it may be possible to discriminate different forms of retinal ischaemia completely non-invasively with MRI.

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